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KMID : 0665220080210030386
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Korean Journal of Food and Nutrition
2008 Volume.21 No. 3 p.386 ~ p.390
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Effects of Glycine maxim Extract on the Activity of Tyrosinase Promoter
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Chin Jong-Eon
Kim Kwan-Chun
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Abstract
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The methanolic extract of Glycine maxim increased the expression of the promoter in B16 mouse melanoma cells harboring a tyrosinase promoter. Extract concentrations of 10 and 100 resulted in tyrosinase promoter expression rates of approximately 113% and 184%, respectively, as compared to the control. The fraction layers consisting of butyl alcohol and methylene chloride improved expression effects on the tyrosinase promoter. In particular, the butyl alcohol fraction evidenced a high expression rate at 100 . In the MTT assay, the methanolic extract did not evidence cytotoxicity at concentrations under 500 . Therefore, the results observed with the extract of Glycine maxim showed that the substance exerted a positive effect on the tyrosinase promoter.
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KEYWORD
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Glycine maxim, tyrosinase promoter, B16 mouse melanoma cell
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